Hisamitsu

With our credo of “bringing relief to patients via transdermal patches” in mind, we are steadily endeavoring to research and develop TDDS products.

We are working on R&D of various medicinal products to achieve well-being for people around the world. We focus especially on developing products based on the transdermal drug delivery system (TDDS), which deliver active ingredients into the body from the skin when they are applied. Our remarkable TDDS products are expected to be applied to a much wider therapeutic area. To improve patients’ quality of life (QOL), we pursue the possibility every day of applying TDDS to pharmaceutical substances that have been considered difficult to convert into TDDS products.

Once a TDDS product is applied, the active pharmaceutical ingredients permeate the skin. They then pass through the stratum corneum, go into the epidermis, penetrate into the dermis, and finally are absorbed into peripheral capillary vessels to be distributed into the rest of the body.

Although some pharmaceutical substances diffuse via skin appendages such as hair follicles and sweat glands, the ratio of such diffusion for most pharmaceutical substances is considered very low.

• ・It can maintain an adequate concentration in the blood for a long time.
• ・It can avoid the first-pass effect in the liver.
• ・It can reduce systemic adverse reactions such as gastrointestinal tract disorders.
• ・It can be applied to infants, elderly people, and patients suffering from dysphagia.
• ・It can be discontinued easily by peeling off the patch if adverse reactions occur.